What is MUSE therapy for erectile dysfunction?

The pouches are composed of aluminium foil/laminate.

Adjunct to other tests in the diagnosis and management of erectile dysfunction. Navigation menu, for these therapies, aprostadil, which is the same chemical produced by an erect penis, is injected into the shaft of the penis to help blood flow. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. No conclusions can therefore be drawn regarding the safety or efficacy of this combination. What is peyronie's disease?, sit or stand in a comfortable position in a warm, well-lit room. It is easier to administer MUSE if the urethral passage is moistened, so it helps to urinate before inserting the pellet.

Dosage may be increased in a stepwise manner (to 1000 micrograms), or decreased (to 250 or 125 micrograms) under medical supervision until the patient achieves a satisfactory response.

If your dose is different, do not change it unless your doctor tells you to do so. Erectile impotence is the most common complaint among men with MS, but other sexual issues can also be present. Prostaglandins like alprostadil cause increased blood flow to certain areas of the body by causing the blood vessels in the area to widen. This will separate the medicated pellet from the applicator tip (Fig. )An erection that lasts longer than 3 hours or is painful. A very fine needle is inserted into the side of the penis, administering medication directly to dilate the arteries and creating an erection.

It is normal for the penis feel more sensitive than usual following administration. Each transurethral delivery system contains alprostadil 1,000 µg. About the author, blood loss is typically small. Once inserted, push the button on the end of the applicator, and then hold it in place for at least five seconds. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.

What is urethral treatment? In the 14 years or so since Viagra was introduced in 1998, the number of men diagnosed with erectile dysfunction (ED) has increased by a whopping 250 percent. Only be sold with a prescription from a licensed GP. For use in the urethra, alprostadil is made into a very small pellet, which is inserted using a special applicator. Ed drugs and the heart, the one that impacts blood vessel walls is inhibited by the drug’s active ingredient. Side effects include pain (17%), hematoma or ecchymosis (1. )The SHIM (abridged 5-item version of IIEF) questionnaire was sent to 27 patients using MUSE therapy for treatment of ED following RP.

  • The type of surgical procedure was determined by a chart review and confirmed by the questionnaire.
  • MUSE is not intended for co-administration with any other agent for the treatment of erectile dysfunction (see also 4.)

Other Versions

Make an appointment today with the knowledgeable health care providers at Alarcon Urology to discuss your treatment options. Ask your doctor if you have any questions. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. It is premixed and must be kept refrigerated and the user must load a syringe with the quantity needed.

  • Invicorp may work well for men who have found little success with other ED treatments and some may find it less uncomfortable to use than alprostadil injections.
  • To remove the protective cover from the applicator stem (Fig.)

Further Reading

Make sure you follow the instructions you have been given for disposing of used injections or applicators. Similar documents, as a woman, you're thus able to have children at a higher age (which is not always a good choice though). Usually, it is best to wait between 10 and 30 minutes before having sex. It is important to sit, stand or walk about for 10 minutes after administration.

Side effects include pain at the injection site and an erection that last too long. MUSE is similar to injection therapy, except instead of administering the medication through a needle the medication is administered through a suppository that is put in your urethra at the tip of your penis. MUSE 1000 microgram urethral stick. The occurrence of fibrosis may increase with increased duration of use. As men age, the vessels in their penis weaken, contract and fill with micro-plaque, which can lead to Erectile Dysfunction. This will reduce blood flow to the penis and may reduce the erection. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.

The recommended starting dose is 500 micrograms.

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After this initial period, you can assume different positions leading to sexual intercourse. The amount of medicine that you take depends on the strength of the medicine. Sexual or couples therapy (counseling), in one 2020 study, participants who received DHEA were more likely to achieve and maintain an erection than those on placebo. Do these supplements have side effects?, [3] Sildenafil should not be taken by people on nitrates such as nitroglycerin (glycerin trinitrate), as this may result in a serious drop in blood pressure. How often can I safely use MUSE?

The pellet then dissolves and the medication enters the blood-filled spaces of the penis (corpora cavernosa), where it works to cause an erection. Alprostadil is a vasodilator, which means that it works by widening (dilating) blood vessels to improve the flow of blood. The reasons given for discontinuation were: After administration, the erection process will begin within 5 – 10 minutes, and may last 30 – 60 minutes. There are 4 dose strengths available:

Avoid activities such as driving or operating machinery during this time. We cannot give individual medical advice, but we can answer your questions on any sexual problems and put you in touch with local specialist practitioners. It’s important to understand the ed treatment we prescribe and the potential risks. Patients on anticoagulants or with bleeding disorders may have an increased risk of urethral bleeding. Do not use alprostadil suppositories if you have a penile implant unless advised by doctor. You will also need to be shown how to prepare the mixture for injection.


Although harm to the fetus is unlikely, using a condom will protect the fetus from exposure to this medicine. The usual starting dose of alprostadil is 250 µg, and depending on your response to the medication, it may be increased up to 1,000 µg as directed by your doctor. The therapy can be prescribed for men with multiple sclerosis (MS) who experience erectile dysfunction. Ask your doctor or pharmacist for more information. Side effects include hypotension, reflex tachycardia, and nasal congestion. Serious side effects have been reported with Muse. If you have an erection lasting more than 4 hours, seek immediate medical help to avoid long-term injury.

An ice bag (such as frozen peas) wrapped around the penis for a short time may also be effective (but don’t overdo this – you want to cool the area not freeze it!) The χ2 test was used to compare categories (NS vs non-NS). Your therapy will depend on the cause of ED, your age, your health and you and your doctor's preferences. Ask your pharmacist about the side effects of each medicine you take. 48 Linet and Neff 49 concluded that alprostadil produced full erections in 70% to 80% of patients. The best penis pumps for men, iCI Alprostadil may be used as a mixture with two other drugs to treat ED. Fifty-two percent (14/27) with mean IIEF-5 score 10.

  • Your GP will usually only recommend it if you have already tried other forms of treatment, such as PDE-5 inhibitors (like Viagra) or psychological therapies (like CBT).
  • The following side effects have been reported by at least 1% of people taking this medication.
  • Usually, an erection occurs within 5 to 20 minutes after the pellet is inserted.
  • Store unopened foil pouches in a refrigerator.


If your erection lasts longer than 4 hours, you should go to a hospital casualty unit or Accident and Emergency Department as soon as you can, because a long delay may damage the penis. MUSE can be stored at room temperature (below 30°C) for up to 14 days prior to use. Call your doctor for medical advice about side effects. MUSE (alprostadil) is indicated for the treatment of erectile dysfunction. This condition is called priapism. It will also make the blood flow to the penis and thus your erection will be improved. MUSE is contraindicated in the following patients: If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist for further advice.

This allows more blood to flow into the penis and get trapped there, which helps you get and keep an erection. Urban thesaurus, this post originally appeared at The Good Men Project. This medicine usually begins to work in about 5 to 10 minutes. If the erection lasts for 2 hours, try to reduce the erection by methods suggested by your doctor. Bleeding problems—Chance of bleeding in the urethra may be increased. Men should not use MUSE more than twice in 24 hours.

Available online: (” on the other side.) Many medications can cause side effects. The goal of this medication is to achieve erections that last from 30 minutes or up to one hour. Please review Figure 6a, the anatomy of the penis. If you buy any medicines, always check with a pharmacist that they are suitable to take with your other medicines. The applicators are made from radiation-resistant medical-grade polypropylene.


Latex condoms can protect against these sexually transmitted diseases. These pellets are part of a therapy called medicated urethral system for erection (MUSE). Avoid touching the applicator stem and tip. Keeping the penis upright, roll it between your hands so that the alprostadil can cover the inside of the urethra. According to the P-Shot creators, the treatment has a satisfaction rate of around 85%.

Make sure your doctor knows about any drugs you are using to lower blood pressure before you start using MUSE.

Many people using this medication do not have serious side effects. Browse by topic, this medicine is also used to treat erection problems in men. Also, your erection may continue after orgasm. 2%) patients reported an improved erectile function after using MUSE (2. May make these conditions worse. Most of the time Alprostadil will begin to worth after the suppository has been allowed to activate for between 5 and 15 minutes. Misoprostol is another synthetic prostaglandin E 1 analog used to prevent gastric ulcers when taken on a continuous basis, to treat missed miscarriage, to induce labor, and to induce abortion.

Viagra, Levitra, and Cialis

Alprostadil causes smooth muscle relaxation, vasodilation, and inhibition of platelet aggregation. The only contraindications to therapy are sickle cell anemia, severe psychiatric disorders, severe venous incompetence, and severe systemic disease. This is not a complete list of possible side effects. Considering the many causes for this disorder (including medications, health contributors, stress, fitness, to name a few), it’s important to know there are options available for just about every contributing factor. It’s recommended to either sit or get up and walk for around 10 minutes following application. In view of the number of negative in vitro results and the lack of evidence for genotoxicity in two in vivo tests, it is considered that the positive results obtained in these two in vitro tests are of doubtful biological significance. Lycopene in tomatoes and pink grapefruit, former smokers were defined as those who had stopped smoking more than 1 year before. It can produce an erection in about 5 to 10 minutes, but this varies from person to person. Wash and dry your hands.

The effects of combinations of alprostadil with other treatments for erectile dysfunction (e.

By activating your account, you will create a login and password. • If this treatment is ineffective and a rigid erection has lasted for more than 6 hours, penile aspiration should be performed. Before use, you should make sure you read these, to help ensure the medicine is effective, and minimise the risk of side effects. Contact your doctor if you experience these side effects and they are severe or bothersome. Alprostadil, what they found was that ED alone put the study participants at double the risk of heart problems, including heart attack, stroke, sudden cardiac death and cardiac arrest. The number of patients discontinuing treatment for multiple reasons was calculated as a percentage of the total. A very serious allergic reaction to this drug is rare. The maximum dose of phenylephrine should be 1 mg, or adrenaline 100 micrograms (5ml of the solution). For these reasons, before you start using alprostadil it is important that your doctor knows:

If used, ice packs should be applied alternately to each inner thigh for a period not exceeding 10 minutes. Underlying treatable medical causes of erectile dysfunction should be diagnosed and treated prior to initiation of treatment with MUSE. Each transurethral delivery system contains alprostadil 250 µg. GoodRx is not available outside of the United States. All patients were followed at 6- to 9-month intervals. Your doctor will choose the appropriate dose of alprostadil for you. Approximately 96% of alprostadil is locally metabolized within 60 minutes. All 54 patients answered IIEF-15 questionnaire9 and their spouses/partners completed the corresponding spousal questionnaires.

Treatment with MUSE should be discontinued in patients who develop penile angulation, cavernosal fibrosis, or Peyronie's disease.

How should I use this medication?

MUSE should not be exposed to high temperatures or placed in direct sunlight. If you have high blood sugar levels (diabetes mellitus). The MUSE system uses an applicator to insert a pellet of medication into the urethra (the tube that urine passes through in the penis). Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: MUSE is considered not as effective as injection therapy and can cause pain and irritation, but it can be a good option for those men who don’t want to use a needle. Some men may feel a burning sensation that can last for an hour or two, but this should not interfere with intercourse.

Keep all medicines out of the reach and sight of children. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. Turkey breast, there’s more health benefits to spicy foods than a healthy libido. Lie down immediately and raise your legs. Important safety information, if you suffer from prostate enlargement, had prostate surgery or don’t have prostate at all, you don’t have to be afraid of using the male-enhancing pills which fight erectile dysfunction. MUSE usually causes an erection in 5-10 minutes that lasts for up to an hour. How should I use this medication? Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

It helps treat the symptoms of erectile dysfunction because it is a ‘vasodilator’, which means that it widens blood vessels.

The medicated pellet has been specially developed to dissolve in the small quantity of urine that remains in the urethra after urination. Men who are unable to resolve or improve naturally or with other medical treatments. How should this medicine be used?, doctors may inject a "contrast agent" into the person's bloodstream that causes vascular tissues to stand out against other tissues. Alprostadil is rapidly metabolised, both locally and in the pulmonary capillary bed; metabolites are excreted in the urine (90% within 24 hours) and the faeces. If you feel any stinging, continue this motion to help stop it. By decomposing plaques, PulseWave restores your energy and enhances your performance. If they remain unused after these times, they should be disposed of. Alprostadil belongs to a family of medications known as prostaglandins. If the erection is not reversed, the blood supply to the penis may be cut off and permanent damage may occur.

Call your doctor if you suspect you may require a dosing adjustment.