When High Blood Pressure Drugs Cause Erectile Dysfunction

In addition, participants were randomized to receive either placebo (n=235) or one of five drugs representing commonly used classes of antihypertensive agents:

To cut to the chase, both diuretics and beta blockers are good at lowering high blood pressure, but sometimes they may also come with side effects, which include erectile dysfunction. Sources of funding: 1314 Part of the relationship generally found between age and sexual dysfunction may be due to blood pressure differences between older and younger men. This article originally appeared in Cleveland Clinic Men’s Health Advisor. History[edit], is there any new curve or bend to your penis to suggest Peyronie’s disease? Sumiye L, Vivian AS, Frisof KB, Podany EC "Potassium loss associated with hydrochlorothiazide versus chlorthalidone. "

It is possible that men predisposed to impotence problems when taking chlorthalidone manifest impotency early on, whereas with other drug treatment (or no drug treatment), impotency takes a more natural course, relating to aging and perhaps blood pressure level. If there's any doubt about your safety, your doctor will order a stress test to measure the effects of exercise on your heart. Related articles, these data suggest that restoring serum testosterone levels to normal had a positive effect on libido as well as erectile function in more than 50% of the study subjects. Fears that it will happen again might lead men to avoid sex — and affect the relationship with their sexual partner. However, in ED, endothelial NO synthesis is reduced and there is increased endothelial cell death (Figure 2).

  • If your doctor says it's OK, you may be able to stop taking blood pressure medications temporarily to see if your sex life improves.
  • The rate of apparent cessation of these problems was highest in the doxazosin group, with none of the eight men reporting these problems at 24 months and only one at 48 months.

(8%) than placebo at 24 months, but this percentage did not differ significantly from that of placebo. 9% of women reported problems with sexual function. Final results with regard to blood pressure, cardiovascular risk, and quality of life.

Diltiazem, Amlodipine, VerapamilAlpha blockers: The more your doctor knows about you, the better he or she can treat your high blood pressure — and help you maintain a satisfying sex life. Some side effects may not be reported. Sexual function was ascertained by physician interviews at baseline and annually during follow-up.

  • Clonidine and chlorthalidone can pass into breast milk and may harm a nursing baby.
  • Katz FH, Eckert RC, Gebott MD "Hypokalemia caused by surreptitious self-administration of diuretics."
  • Consuming large quantities of grapefruit products while taking these statins can lead to greater concentrations of the medication in your bloodstream, increasing your risk of side effects.
  • She hardly mingled with any neighbours or friends, exceptingwith Mr and Mrs Jackson, of Coleraine.
  • Digoxin is indicated for treatment of atrial fibrillation and heart failure in functional stage III–IV according to the New York Heart Association (NYHA).

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16 However, compared with patients treated with propranolol, enalapril, had a favorable effect,25 and in cross-over studies where either the ACE-inhibitor, lisinopril, or the angiotensin II receptor antagonist, valsartan, were compared to β-adrenoceptor antagonist, the number of sexual intercourses were higher in the groups of patients treated with lisinopril and valsartan. The logistic regression model included covariate terms described previously in ANCOVA models. Peripheral neuropathy can sometimes affect nerves in the penis that control erections. 17,18,19 It is difficult to evaluate whether the dose of thiazide diuretic applied for the treatment of hypertension in these studies plays a role for the frequency of ED, but patients in the study by Chang and colleagues15 were treated with 50 mg/day of hydrochlorthiazide or chlorthalidone which is above the 12.

12,13 However, these agents are contraindicated in patients who require treatment with nitrates and in those with angina who may need nitroglycerine.

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Patients were included in the thiazide diuretic group if they took any one of the following medications: Has your relationship with your sexual partner changed recently? The incidences of erection dysfunction during follow-up in men were 9. Follow the diet and medication plan created for you by your doctor or nutrition counselor.

[1] It is specifically a thiazide-like diuretic.

The analyses of safety in the 14 studies included all enrolled patients. Kostenfaktoren: 68 Therefore, although information regarding anticoagulants and erectile function is lacking, these drugs do not appear to impose a major risk for ED. Grapefruit and its juice may also interact with a number of other medications. Of the four patients who were on thiazide diuretics but did not have a hypertension diagnosis, the diagnoses were: Carney SL, Morgan TO "Diuretic-induced hypokalemia and altered renal function. "At a dose of 20 mg, 73% to 80% of sexual intercourse attempts were completed successfully between 30 minutes and 36 hours after dosing. Make sure the medications you or your partner takes are not the reason why you can’t have fun in bed!

If you have high blood pressure, you usually don't have to live with a loss of sexual satisfaction. Hypertension is associated with severe erectile dysfunction. Accessibility links, urethral suppository:. If you are being treated for high blood pressure, keep using this medicine even if you feel well.


Like men, women can experience anxiety and relationship issues due to sexual dysfunction. This relationship persisted with controls for age and previous use of antihypertensive medication. Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. The people everywhere began Erectile Dysfunction Is Your Best Choice to discuss how the princess of the Susa country tens of thousands of miles away in the West is beautiful and unparalleled. In other instances, your doctor and pharmacist will advise you to take a medication with food to reduce stomach irritation and to improve the drug’s absorption and effectiveness. Rates of erection problems were also compared among treatment groups in the 12% of men who reported an erection problem at baseline (Table 4). They are relatively inexpensive and effective, and they are recommended in the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC VII) as first-line therapy in uncomplicated hypertension. Certain blood pressure-lowering drugs — including angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs) and potassium-sparing diuretics — can lead to high potassium levels (hyperkalemia).

5-50 1 Most effective diuretic class for lowering blood pressure in most patients Usual doses mitigate adverse metabolic effects Chlorthalidone is 1.


By increasing the delivery of sodium to the distal renal tubule, chlortalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism (i. )2,3 It has affected 30 million men in the US alone. If you still have side effects, talk to your doctor about other possible medications that may have fewer side effects. Stratification by age level showed that SBP ≥140 mm Hg was associated with twice the rate of erection problems for both men younger than 60 years and men 60 years old or older (data not shown).

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That said, there are some that seem more likely than others to affect sexual function. The incidence of sexual problems reported by women was low (as measured in TOMHS), regardless of treatment, suggesting that sexual dysfunction is not a major concern in drug treatment of women with hypertension. You may report them to the FDA. However, if compelling reasons exist for the use of a particular antihypertensive agent (eg, a β-blocker in a patient with previous myocardial infarction), several options for the treatment of associated ED are available. Kuller L, Farrier N, Caggiula A, Borhani N, Dunkle S "Relationship of diuretic therapy and serum magnesium levels among participants in the Multiple Risk Factor Intervention Trial. "Analyses of TEAEs used the Fischer exact test. Another smaller trial reported on by Chang et al. The rate of erection problems was relatively constant until 60 years of age; for men 60 and older, it was substantially higher.

In this article, we compare the effects over 4 years of five antihypertensive drugs (representing five classes of antihypertensive agents) and placebo, combined with nutritional-hygienic treatment, on sexual function in men and women aged 45 to 69 years with stage I diastolic hypertension in the Treatment of Mild Hypertension Study (TOMHS). I ask what male enhancement pills work with chlorthalidone Erectile Dysfunction Extend Pills you a question, and you have to answer it truthfully, otherwise you can not get the slightest help from Ben Ho Chen Xu tapped the armrest of his seat with his finger gently, and what male enhancement pills work with chlorthalidone Erectile Dysfunction Sexual Healthy spoke after a long time. Erection problems were also reported more than twice as often in men with SBP ≥140 mm Hg than in men with SBP <140 mm Hg; the highest rate of erection problems was in men with SBP ≥140 mm Hg (Figure). Take the missed dose as soon as you remember.

Atuk NO, Owen JA, Jr "Bronchospasm after reserpine. "Vitamin K interactions: The prevalence of minimal ED was 17%; moderate ED, 25%; and complete ED, 10%. One of the more well-known food-drug interactions involves grapefruit and grapefruit juice and certain cholesterol-lowering statin medications — namely, atorvastatin (Lipitor®), lovastatin (Mevacor®), pitavastatin (Livalo®) and simvastatin (Zocor®). This would be a huge development in terms of management options for patients with ED and IHD. Newball HH, Byar DP "Does reserpine increase prolactin and exacerbate cancer of prostate? "The combination of clonidine and chlorthalidone treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. Keep using clonidine and chlorthalidone as directed, even if you feel well.

Erectile dysfunction (ED) affects about 30 million American men.

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While there have been no reports of harm to nursing infants, consult your doctor before breastfeeding. Lewis WH "Iatrogenic psychotic depressive reaction in hypertensive patients. "Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. Probability values are reported comparing each active treatment with placebo and comparing the five active drug groups (4 df).


36 Structural changes of the penile vasculature or erectile tissue also contribute to the reduced vasodilation, since proximal atherosclerotic lesions lead to reduced increases in intracavernous pressure after infusion of papaverine,34 while lumen narrowing in the arteries feeding the penis is an explanation for increased penile vascular resistance and less increase in intracavernous pressure in spontaneously hypertensive rats (SHR). Previous studies reported that there is a strong chance of future cardiac events when ED occurs in younger men compared with older men. Be prepared to answer questions your doctor may ask, such as: These are among the most widely used antihypertensive agents.

A separate analysis was done for men reporting any erection problems at baseline for assessment of whether treatments differed in modifying the rate of existing sexual problems. 48 The risk of ED is relatively high in patients with known CVD. 4% of men and 4. Most of the participants in the chlorthalidone group developing erection problems through 24 months experienced the problem in the first year (8 of 12 men); a majority of them continued on diuretic medication. 54 These events cause penile erection. Exclusion criteria included unstable cardiovascular status (eg unstable angina, myocardial infarction or myocardial revascularization within the prior 90 days); a recent history of stroke or spinal cord trauma; use of nitrates, cancer chemotherapy or antiandrogens; failure to achieve any erection following radical prostatectomy or pelvic surgery; or clinically significant penile deformities or penile implants.


Share with each other the types of sexual activity you enjoy most. 7% through 24 and 48 months, respectively, and were related to type of antihypertensive therapy. There are so many good things in Daqin, far more than porcelain and enamel that have been seen in the body, so a group of people shouted with excitement. The metabolic side effects of chlorthalidone, as with other thiazide diuretics, may require electrolyte monitoring and/or potassium supplementation.

—— We carried out a randomized placebocontrolled trial of the effect of thiazide diuretics on quality of life in mildly hypertensive men between the ages of 35 and 70 years. Oh SJ, Douglas JE, Brown RA "Hypokalemic vacuolar myopathy associated with chlorthalidone treatment. Health solutions from our sponsors, latency to ejaculation was also severely affected. "7%), which was significantly higher than placebo (4. Rates of decrease in sexual activity through 48 months were more heterogeneous than at 24 months, ranging from 10% (acebutolol group) to 26% (amlodipine group, P=. )These regulatory factors regulate the blood flow to the penis by controlling smooth muscle contractility and subsequent vasoconstriction and vasodilatation. Wassertheil-Smoller S, Oberman A, Blaufox MD, Davis B, Langford H "The Trial of Antihypertensive Interventions and Management (TAIM) Study. "

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You may need to use blood pressure medicine for the rest of your life. Decreased erectile function has been observed in cholesterol-fed rabbits,34 diabetic35 and hypertensive36 rats and can be ascribed to impaired vasodilation and hence reduced blood flow to penis. Every effort has been made to ensure that the information provided by Cerner Multum, Inc.

Pharmacology of Cardiovascular Drugs

Rather than improving erectile function most of these studies suggest that treatment of cardiovascular disease worsens erectile function. Causes of ed: surgery, these can include blood counts, urinalysis, lipid profile, and measurements of creatinine and liver enzymes. The risk of hypokalemia, hypomagnesemia, hyponatremia, and hypochloremia appears to be dose-related. Today, I want to ask Hou Ye to forgive Asiya is ignorance, and at the same time give Asia a way to point out, As long as there is a glimmer what male enhancement pills work with chlorthalidone Erectile Dysfunction Male Enhancement of hope, Atheia is willing to go to anything, I am not afraid of suffering, and even willing to give up the role of princess, no matter how successful or not in the end, I will never forget the kindness of Grandpa Woman Chen Xu couldn t help but sigh. Clonidine and chlorthalidone can make your skin more sensitive to sunlight and sunburn may result. 39% of patients were not taking antihypertensive medication at baseline (mean diastolic pressure 90 to 99 mm Hg), and 61% were taking antihypertensive medication (mean diastolic pressure 85 to 99 mm Hg). (0%) in all other groups combined, suggests that doxazosin may reduce sexual dysfunction in men. 902 patients 45 to 69 years of age (mean age 55 y, 62% men) who had stage I diastolic hypertension and no cardiovascular disease.

You should not use chlorthalidone if you are unable to urinate, or if you are allergic to sulfa drugs. Donatelli A, Geisen L, Feuer E "Case report of adverse effect of reserpine on tardive dyskinesia. "97 SBP (≥140 vs <140 mm Hg) 2.

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Frequency not reported: And a number of factors — like what you’re eating and drinking, and when — can interfere, creating undesired (and potentially serious) effects. In most instances, this is an undesirable effect and every effort is made to minimize the sexual adverse effects of therapeutic pharmacological agents.

79 The efficacy and safety of gene and stem cell therapy in patients with ED and IHD need to be extensively investigated because both seem to have the potential to correct underlying abnormalities in ED.

Many medicines and recreational drugs can affect a man's sexual arousal and sexual performance. For the purpose of the analyses presented here, only data gathered after 12 weeks of treatment are presented for the Erectile Function (EF) domain of the International Index of Erectile Function (IIEF) questionnaire and the Sexual Encounter Profile (SEP) diary. 5-75 1 ACE, angiotensin-converting enzyme; ARB, angiotensin receptor blocker; CKD, chronic kidney disease. These side effects may go away during treatment as your body adjusts to the medicine.

Get up slowly and steady yourself to prevent a fall. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. One study reported that 91 (13%) of 699 men prescribed spironolactone, alone or in association with another antihypertensive treatment, developed dose-related gynecomastia that was reversible.

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In the TOMHS, the incidence of ED in patients treated with enalapril was similar to that in patients given placebo. The secondary cause of ED involves arteriosclerosis, diabetes or psychogenic disturbances. A rare case of paroxysmal atrial tachycardia with block associated with reserpine in a patient who was not taking a digitalis preparation has been reported. ED may be linked to diminished penile perfusion pressure associated with a decrease in mean arterial pressure and underlying peripheral vascular disease, or it may be an intrinsic drug side effect. Other drugs may interact with chlorthalidone, including prescription and over-the-counter medicines, vitamins, and herbal products.

Reprint requests to Richard H. And, in rare cases, the extra exertion could trigger a heart attack. During follow-up, the initial dose of step 1 medication was doubled if diastolic pressure was ≥95 mm Hg on three successive visits or ≥105 mm Hg at a single visit. Chlortalidone is banned for some sports (including cricket) because it is a diuretic, and can be used to reduce body weight or to mask the concomitant use of performance-enhancing drugs. A community-based longitudinal study of 2,000 hypertensive women. Thiazides and the chemically related drug, chlorthalidone, have been implicated as the cause of necrotizing vasculitis, psoriasiform eruptions, and pseudoporphyria (bullous photosensitive lesions) in rare cases.

In conclusion, long-term incidence of erection problems in treated hypertensive men is relatively low but is higher with chlorthalidone treatment. Causes of ED may be of primary developmental origin or secondary. Erection problems in men at baseline were positively related to age, systolic pressure, and previous antihypertensive drug use. In contrast, others in a cross-over study of 22 men with hypercholesterolemia randomized for placebo, simvastatin, or lovastatin, found an increase in nocturnal tumescence after 2 weeks, although the increase was not significant after 6 weeks treatment. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: But the impact on your sex life may be obvious.

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Furthermore, a subgroup-by-treatment-group-interaction term was added to test whether treatment effect was similar between subgroups. The patient sample was relatively small, and when it was divided into the 5 drug groups plus 1 placebo group, the numbers in each group reached levels at which major differences were necessary to establish significance. Tell your doctor about any unusual or bothersome side effect. Differences among groups in incidence rates of problems maintaining an erection were similar to those observed regarding problems obtaining an erection. Explore various ways to be physically intimate, such as massage or warm soaks in the tub. For women who have decreased sexual satisfaction, it's not yet proved that high blood pressure is to blame. 65 Conti et al.

What is the most important information I should know about clonidine and chlorthalidone?

The wise man Aristotle wrote Whoever seizes the wealth of Susa can fight for wealth with the god Zeus. How should I take clonidine and chlorthalidone? Always consult with your doctor first! Immunologic side effects are rare. Reffelmann, T, Kloner, RA. There is also the possibility of underreporting of sexual dysfunction, despite efforts to minimize this by having physicians query participants.

Incidence rate of erection problems were different for chlorthalidone at 24 months compared to placebo treated hypertensive patients, but were similar to the placebo group at a 48-month follow-up. Chlortalidone is the official name of the medication according to the (INN/BAN), which is the medication naming system coordinated by the World Health Organization. Perry HM, Jr "Some wrong-way chemical changes during antihypertensive treatment: "Stem cells are pluripotent cells that can be produced from multiple regions within the body.

44,45,46 Nitrates relieve pain, but they have not been shown to prolong survival in chronic heart failure unless they are taken in combination with the peripheral vasodilator, hydralazine.

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Thiazide diuretics, beta-adrenoceptor antagonists, calcium channel blockers, ACE inhibitors, and angiotensin II receptor antagonists are considered as first-line drugs for treatment of hypertension (Table 1). This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Where can I get more information?

Studies have shown that tadalafil significantly improves erectile function. Next slideshow title, tobacco CYP3A4 PDE5I:. What are some of the most common food-drug interactions? Funding was provided by the National Heart, Lung, and Blood Institute, National Institutes of Health (NIH R01-HL-34767) and by the following pharmaceutical firms:

Baseline sexual function in men was not significantly related to obesity, alcohol intake, smoking, or physical activity level (data for physical activity not shown), although the small percentage of current cigarette smokers reported the highest rate of sexual problems (20%) among the subgroups considered (P=.

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If ED occurs, switching to an agent with fewer sexual side effects may be an option. Since the introduction of PDE-5 inhibitors, other modalities for the treatment of ED, such as urethral suppositories, penile injections, and vacuum pumps, have fallen into disuse. In an unfortunate twist, many drugs that are good for your heart can be hard on your sex life. Chlorthalidone-induced hypokalemia has resulted in hypokalemic myopathy in rare cases. He or she may be able to substitute for a different one. (5%] reported difficulty in having an orgasm). Even if you do not take blood pressure drugs, you should get your blood pressure checked as high BP also can be a sign of ED. Hydrochlorothiazide (HCTZ) is the most frequently used thiazide diuretic in the United States, although chlorthalidone is the diuretic that was used in many of the landmark clinical outcomes trials.

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Though its usually safe to take erectile dysfunction drugs (Viagra, Levitra, Cialis) with high blood pressure medication, don't take them with nitrates -- this can cause a life-threatening drop in blood pressure. For SBP, the rate was higher, with levels ≥140 mm Hg; men with SBP ≥140 mm Hg had more than twice the rate of erection problems of men with SBP <140 mm Hg. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. IHD can be used to predict the risk of ED because both conditions have the same risk factors. The rates for any erection problems in the chlorthalidone and placebo groups were 17.

These agents, which are recommended in JNC VII as first-line treatment for hypertension in patients with certain comorbid conditions, have not been associated with high rates of ED. 6 Diuretics have been associated with an increased frequency of ED. Luxenberg J, Feigenbaum LZ "The use of reserpine for elderly hypertensive patients. International journal of impotence research, creates erectile problems in healthy adult men enhancement drugs male at walmart and women. "Analysis was by intention to treat.

57 With problems at baseline, n 13 11 11 8 8 13 Through 48-mo visit Problem obtaining or maintaining erection 5 (38. )Segal MS "Bronchospasm after reserpine. "Feldman and colleagues2 evaluated the incidence and prevalence of ED in the general population using results from the Massachusetts Male Aging Study, a random, cross-sectional, sample survey of 1709 men between the ages of 40 and 70 years. 51 In addition, a relation of digoxin to low plasma testosterone levels and decrease in sexual desire has been found.

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15,16 In contrast, others have found no discernable effect of thiazide diuretics on sexual function. Impotence and decreased libido are the more frequent sexual side effects with spironolactone. Reagiert wird hier oft mit dem Einsatz von mehr Sedativa. Few women (n=7) reported a problem having an orgasm (2%), making comparisons among subgroups difficult. A problem for many men, though, is that some types of blood pressure drugs can cause erectile dysfunction. Alpha-blockers, calcium channel blockers, and angiotensin-converting enzyme inhibitors seem to have a neutral effect on erectile function. For some men, the decreased blood flow makes it difficult to achieve and maintain erections — often referred to as erectile dysfunction.

Chlortalidone is considered a first-line medication for treatment high blood pressure.

Obel AO "Efficacy and tolerability of long term oxprenolol and chlorthalidone singly and in combination in hypertensive blacks. "Pairwise comparisons were made among the active treatment groups if the probability value comparing the active groups was less than. This drug passes into breast milk.

So you may be advised to consume more potassium in your diet.